Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 3/20 | 0.42 |
| ▸ | F11 | P03951 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414217 | 0.84 | F11 (0.39) | HPGDRAB9AF11SMN1; SMN2 | |
| SCHEMBL478811 | 0.79 | F11 (0.58) | ALDH1A1TSHRLMNAPKMHPGD | |
| SCHEMBL3411795 | 0.78 | SMN1; SMN2 (0.39) | HPGDRAB9AF11SMN1; SMN2 | |
| SCHEMBL1196923 | 0.73 | PTPRB (0.49) | ALDH1A1TSHRLMNAPKMHPGD | |
| SCHEMBL478814 | 0.72 | F11 (0.43) | ALDH1A1PTPRBF11 | |
| SCHEMBL479154 | 0.72 | F11 (0.51) | ALDH1A1TSHRLMNAPKMHPGD | |
| SCHEMBL1196969 | 0.72 | F11 (0.56) | ALDH1A1TSHRLMNAPKMHPGD | |
| SCHEMBL938642 | 0.71 | F11 (0.44) | ALDH1A1TSHRLMNAPKMHPGD | |
| SCHEMBL938641 | 0.71 | F11 (0.44) | ALDH1A1TSHRLMNAPKMHPGD | |
| SCHEMBL13875359 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TSHRLMNAPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265601-B1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2265601-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114677-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-17 | — | — | WO | disclosed |