Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 15/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411795 | 0.94 | SMN1; SMN2 (0.39) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL479094 | 0.84 | ALDH1A1 (0.42) | F11SMN1; SMN2RAB9AHPGD | |
| SCHEMBL478865 | 0.76 | F11 (0.52) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL479338 | 0.76 | F11 (0.53) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL479341 | 0.76 | F11 (0.53) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL17022187 | 0.69 | F11 (0.51) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL1197260 | 0.69 | SMN1; SMN2 (0.44) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL1197053 | 0.69 | F11 (0.63) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL3414032 | 0.69 | PDE4A (0.42) | F11SMN1; SMN2ROCK1HPGD | |
| Hydrochloric Acid SCHEMBL29758967 | 0.68 | F11 (0.50) | F11SMN1; SMN2NPC1RAB9AKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265601-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114677-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-17 | — | — | WO | disclosed |