Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.51 |
| ▸ | RARG | P13631 | 4/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.41 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27834343 | 0.87 | PDE5A (0.55) | RORCRARGPDE5ASMN1; SMN2TEAD1 | |
| SCHEMBL4793748 | 0.86 | RORC (0.49) | RORCRARGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4792507 | 0.81 | MAPT (0.47) | RORCRARGNOTUMPDE5ARAB9A | |
| SCHEMBL928140 | 0.80 | PTGER4 (0.50) | PDE5ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3157520 | 0.79 | RORC (0.47) | RORCRARGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4792952 | 0.77 | TEAD1 (0.63) | RORCRARGPDE5AABCB1TEAD1 | |
| SCHEMBL12253498 | 0.76 | GAA (0.67) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL3347837 | 0.74 | L3MBTL1 (0.38) | RORCRARGPDE5ANPC1RAB9A | |
| SCHEMBL4792972 | 0.74 | SCN9A (0.42) | NOTUMPTGS1PTGS2 | |
| SCHEMBL4795769 | 0.74 | EGLN2 (0.41) | NOTUMPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937647-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |