Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 13/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 11/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 11/20 | 0.43 |
| ▸ | PTGIR | P43119 | 6/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792493 | 0.81 | PTH1R (0.42) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4906720 | 0.81 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4792633 | 0.80 | PTH1R (0.44) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4794483 | 0.80 | PTH1R (0.44) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4795892 | 0.80 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4881501 | 0.80 | PTGIR (0.40) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4794906 | 0.79 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4878946 | 0.79 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4795965 | 0.79 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4794147 | 0.79 | PTGIR (0.40) | ADRA2AADRA2BADRA2CPTGIRAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |