Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.49 |
| ▸ | MGAM | O43451 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | SI | P14410 | 5/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.42 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104601 | 1.00 | CENPE (0.51) | CENPEHPSEMGAMGAASI | |
| SCHEMBL2105475 | 0.88 | CENPE (0.48) | CENPEHPSEKDM4ENPC1ALDH1A1 | |
| SCHEMBL2104691 | 0.88 | CENPE (0.49) | CENPEHPSEGAAKIFC1KDM4E | |
| SCHEMBL2104165 | 0.85 | CENPE (0.46) | CENPEHPSEKIFC1 | |
| SCHEMBL13644431 | 0.84 | CENPE (0.45) | CENPEHPSEKIFC1HPGDSMN1; SMN2 | |
| SCHEMBL4400479 | 0.84 | CENPE (0.45) | CENPEHPSEKIFC1MME | |
| SCHEMBL2103765 | 0.84 | CENPE (0.45) | CENPEHPSEKIFC1MME | |
| SCHEMBL2104700 | 0.84 | CENPE (0.45) | CENPEKIFC1PTGDR2 | |
| SCHEMBL4525707 | 0.84 | CENPE (0.45) | CENPEKIFC1PTGDR2 | |
| SCHEMBL3462683 | 0.83 | KIFC1 (0.40) | CENPEHPSEKIFC1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |