Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | PRKX | P51817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104700 | 1.00 | CENPE (0.45) | CENPEHDAC6PTGDR2GUSBKIFC1 | |
| SCHEMBL2104165 | 0.87 | CENPE (0.46) | CENPEHDAC6KIFC1TAS1R3TAS1R1 | |
| SCHEMBL2105475 | 0.86 | CENPE (0.48) | CENPEHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL2104691 | 0.85 | CENPE (0.49) | CENPEHDAC6KIFC1TAS1R3TAS1R1 | |
| SCHEMBL13644431 | 0.85 | CENPE (0.45) | CENPEHDAC6KIFC1TAS1R3TAS1R1 | |
| SCHEMBL4400479 | 0.85 | CENPE (0.45) | CENPEHDAC6KIFC1TAS1R3TAS1R1 | |
| SCHEMBL2103765 | 0.85 | CENPE (0.45) | CENPEHDAC6KIFC1TAS1R3TAS1R1 | |
| SCHEMBL4792553 | 0.84 | CENPE (0.51) | CENPEPTGDR2KIFC1 | |
| SCHEMBL2104601 | 0.84 | CENPE (0.51) | CENPEPTGDR2KIFC1 | |
| SCHEMBL2104338 | 0.83 | CENPE (0.44) | CENPEHDAC6KIFC1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286841-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286841-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | KIF5B, KIF2C, PLK1 | CENPE 54/4885HDAC6 137/4885PTGDR2 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.