Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898278 | 0.72 | USP2 (0.53) | ALDH1A1HSD17B10KDM4EHPGDUSP2 | |
| SCHEMBL4794241 | 0.69 | ACACB (0.41) | ALDH1A1HSD17B10KDM4EHPGDACACB | |
| SCHEMBL4784806 | 0.66 | ALDH1A1 (0.42) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| SCHEMBL28000284 | 0.66 | GRM4 (0.36) | KDM4EHPGDKMT2A | |
| SCHEMBL27927983 | 0.66 | KDM4E (0.49) | ALDH1A1HSD17B10KDM4EHPGDCYP3A4 | |
| SCHEMBL16097795 | 0.65 | IDH1 (0.54) | IDH1 | |
| SCHEMBL13729776 | 0.64 | HSD17B10 (0.36) | ALDH1A1HSD17B10USP2SYKLRRK2 | |
| SCHEMBL15529237 | 0.64 | ALDH1A1 (0.48) | ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL10866954 | 0.64 | MAPT (0.43) | ALDH1A1HSD17B10KDM4EHPGDCYP1A2 | |
| SCHEMBL22731793 | 0.63 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |