Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14207895 | 0.78 | EGFR (0.52) | MEN1KMT2AEGFRPDGFRBKDR | |
| SCHEMBL5333345 | 0.73 | MEN1 (0.59) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL5461512 | 0.72 | MAPT (0.46) | MEN1KMT2ALMNAGAAMAPT | |
| Hydrochloric Acid SCHEMBL5467468 | 0.71 | MAPT (0.45) | MEN1KMT2ALMNAGAAMAPT | |
| Hydrochloric Acid SCHEMBL5475286 | 0.71 | MAPT (0.53) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL5315120 | 0.71 | CSNK2A1 (0.53) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL17837013 | 0.71 | EGFR (0.70) | MEN1KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL7699357 | 0.68 | KMT2A (0.62) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL4784607 | 0.66 | FBP1 (0.50) | EGFRPDGFRBKDR | |
| SCHEMBL14207910 | 0.65 | LMNA (0.36) | LMNAEGFRPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |