Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 14/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16145750 | 0.74 | EGFR (0.52) | FBP1EGFRKDRCDK1ABL1 | |
| SCHEMBL14207895 | 0.73 | EGFR (0.52) | EGFRKDRPDGFRB | |
| SCHEMBL4909767 | 0.70 | FBP1 (0.49) | FBP1EGFRKDRRAPGEF4ABL1 | |
| SCHEMBL14207910 | 0.68 | LMNA (0.36) | EGFRKDRPDGFRB | |
| SCHEMBL16145753 | 0.68 | BRAF (0.73) | — | |
| SCHEMBL30523403 | 0.68 | BRAF (0.73) | — | |
| SCHEMBL6796291 | 0.67 | FBP1 (0.65) | FBP1EGFRKDRCDK1ABL1 | |
| SCHEMBL5564585 | 0.67 | FBP1 (1.00) | FBP1EGFRKDRCDK1ABL1 | |
| SCHEMBL3050490 | 0.65 | TP53 (0.53) | FBP1EGFRKDR | |
| SCHEMBL4781561 | 0.65 | EGFR (0.52) | FBP1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |