Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 4/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 7/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774621 | 0.81 | DHODH (0.41) | DHODH | |
| SCHEMBL4774798 | 0.80 | NOS3 (0.42) | MAOBDHODH | |
| SCHEMBL4878946 | 0.77 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL4794392 | 0.77 | DHODH (0.36) | DHODH | |
| SCHEMBL4780548 | 0.77 | DHODH (0.39) | DHODH | |
| SCHEMBL4795959 | 0.76 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CNISCH | |
| SCHEMBL4774769 | 0.75 | SLC6A2 (0.37) | CYP2D6CYP1A2DHODH | |
| SCHEMBL4793089 | 0.75 | ADRA2A (0.38) | ADRA2AADRA2BADRA2C | |
| SCHEMBL4796492 | 0.74 | TAAR1 (0.42) | TAAR1DHODH | |
| SCHEMBL4780934 | 0.72 | DHODH (0.40) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |