Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774621 | 0.88 | DHODH (0.41) | NOS3NOS1NOS2DHODHHRH2 | |
| SCHEMBL4794392 | 0.85 | DHODH (0.36) | NOS3NOS1NOS2DHODHHRH2 | |
| SCHEMBL4780548 | 0.85 | DHODH (0.39) | NOS3NOS1NOS2DHODHHRH2 | |
| SCHEMBL4794671 | 0.80 | HTR1D (0.51) | DHODHMAOB | |
| SCHEMBL4774769 | 0.80 | SLC6A2 (0.37) | NOS3NOS1NOS2DHODHMEN1 | |
| SCHEMBL4796492 | 0.78 | TAAR1 (0.42) | NOS3NOS1NOS2DHODHGSK3B | |
| SCHEMBL4774672 | 0.78 | NOS3 (0.43) | NOS3NOS1NOS2DHODHHRH2 | |
| SCHEMBL4780934 | 0.78 | DHODH (0.40) | NOS3NOS1NOS2DHODHHRH2 | |
| SCHEMBL4795346 | 0.76 | CTSK (0.41) | DHODH | |
| SCHEMBL4791758 | 0.75 | SREBF2 (0.36) | DHODHGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |