Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 7/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 10/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776169 | 0.68 | TAAR1 (0.36) | NISCHALDH1A1TAAR1 | |
| SCHEMBL693664 | 0.67 | MEN1 (0.37) | ALDH1A1HTTLMNA | |
| SCHEMBL5352074 | 0.67 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL127066 | 0.66 | — | — | |
| SCHEMBL1389079 | 0.66 | NISCH (0.53) | ADRA2AADRA2BADRA2CNISCHMAOA | |
| SCHEMBL27595169 | 0.66 | CXCR2 (0.39) | ALDH1A1MAPTLMNA | |
| SCHEMBL27270344 | 0.65 | — | — | |
| SCHEMBL27606434 | 0.64 | — | — | |
| SCHEMBL28053574 | 0.64 | CHEK1 (0.31) | — | |
| SCHEMBL5350240 | 0.64 | MAOA (0.48) | ADRA2AADRA2BADRA2CNISCHMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | claimed |
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |