Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802221 | 0.99 | ALDH1A1 (0.38) | ALDH1A1BRD4BRD2BRD3GAA | |
| SCHEMBL4798089 | 0.85 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2PIK3CDPIK3CBMTOR | |
| SCHEMBL4732186 | 0.82 | HTT (0.36) | ALDH1A1BRD4BRD2BRD3GAA | |
| SCHEMBL4732586 | 0.81 | HTT (0.38) | ALDH1A1BRD4BRD2BRD3GAA | |
| SCHEMBL4730085 | 0.77 | KMT2A (0.41) | ALDH1A1SMN1; SMN2PIK3CDPIK3CBMTOR | |
| SCHEMBL4736205 | 0.73 | HTT (0.35) | BRD4BRD2BRD3GAAHTT | |
| SCHEMBL4919374 | 0.70 | HTT (0.36) | BRD4BRD2BRD3GAAPIK3CD | |
| SCHEMBL4732359 | 0.70 | BRD4 (0.36) | BRD4BRD2BRD3GAAHTT | |
| SCHEMBL4735483 | 0.70 | BRD4 (0.41) | BRD4BRD2BRD3GAAHTT | |
| SCHEMBL4730155 | 0.70 | CNR2 (0.39) | GAAHTTNPSR1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |