Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802221 | 0.86 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KMT2ALMNAPIK3CD | |
| SCHEMBL4795053 | 0.85 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KMT2ALMNAPKM | |
| SCHEMBL4732243 | 0.83 | CNR2 (0.39) | ALDH1A1GBA1CNR2LMNAPKM | |
| SCHEMBL4730155 | 0.82 | CNR2 (0.39) | GBA1CNR2LMNAPKM | |
| SCHEMBL4798095 | 0.74 | HTR2C (0.39) | ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL4732817 | 0.73 | CNR2 (0.39) | GBA1CNR2NPC1MEN1KMT2A | |
| SCHEMBL4733963 | 0.72 | CNR2 (0.38) | GBA1CNR2NPC1MEN1KMT2A | |
| SCHEMBL4732586 | 0.71 | HTT (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL4732186 | 0.70 | HTT (0.36) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4802225 | 0.69 | KMT2A (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |