SCHEMBL29005378

SCHEMBL29005378

O=C(O)c1nn(-c2ccc(OC(F)(F)F)cc2)c2ccccc2c1=O

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TEAD1 P28347 1/20 0.53
TEAD4 Q15561 1/20 0.53
TEAD2 Q15562 1/20 0.53
TEAD3 Q99594 1/20 0.53
SCN9A Q15858 6/20 0.52
PTGER4 P35408 2/20 0.47
PPARG P37231 1/20 0.45
PPARA Q07869 1/20 0.45
ABCB1 P08183 1/20 0.45
TP53 P04637 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
RORC P51449 2/20 0.43
STAT1 P42224 1/20 0.41
RIPK1 Q13546 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30310996 0.85 TEAD1 (0.56) TEAD1TEAD4TEAD2TEAD3SCN9A
SCHEMBL28971987 0.85 TEAD1 (0.52) TEAD1TEAD4TEAD2TEAD3SCN9A
SCHEMBL13885872 0.83 RIPK1 (0.52) SCN9ARORCSTAT1RIPK1
SCHEMBL8830041 0.83 RORC (0.45) TEAD1TEAD4TEAD2TEAD3SCN9A
SCHEMBL30212108 0.83 RORC (0.45) TEAD1TEAD4TEAD2TEAD3SCN9A
SCHEMBL4795077 0.82 SCN9A (0.57) TEAD1TEAD4TEAD2TEAD3SCN9A
Potassium SCHEMBL10479127 0.82 RORC (0.44) TEAD1TEAD4TEAD2TEAD3SCN9A
SCHEMBL8830115 0.82 RORC (0.44) TEAD1TEAD4TEAD2TEAD3SCN9A
SCHEMBL9569701 0.80 RORC (0.45) TEAD1TEAD4TEAD2TEAD3TP53
SCHEMBL30626343 0.80 TEAD1 (0.40) TEAD1TEAD4TEAD2TEAD3SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230303498-A1 HERBICIDAL CINNOLINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
CN-115802892-A Herbicidal cinnoline derivatives 先正达农作物保护股份公司 2023-03-14 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303498-A1 HERBICIDAL CINNOLINE DERIVATIVES DDT, DERL1, MTX1 TEAD1 3800/4885TEAD4 4243/4885TEAD2 4504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.