Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881352 | 0.84 | HTR2A (0.39) | HTR2AHTR2CMAOB | |
| SCHEMBL4780935 | 0.82 | MAPT (0.45) | MAPTRAB9AGAAPOLBNPC1 | |
| SCHEMBL4727973 | 0.80 | MAPT (0.53) | MAPTRAB9AGAANPC1HTT | |
| SCHEMBL6987618 | 0.77 | MAPT (0.54) | MAPTRAB9AGAAPOLBNPC1 | |
| SCHEMBL4780197 | 0.77 | HTR2A (0.42) | HTR2AHTR2C | |
| SCHEMBL4780191 | 0.76 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL4727771 | 0.76 | HTR2A (0.57) | HTR2AHTR2C | |
| SCHEMBL6979379 | 0.76 | MAPT (0.55) | MAPTRAB9AGAAPOLBNPC1 | |
| SCHEMBL4727184 | 0.76 | HTR2A (0.60) | HTR2AHTR2C | |
| SCHEMBL4778898 | 0.74 | ALDH1A1 (0.37) | MAPTRAB9APOLBHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008027483-A1 | BENZOFURAN DERIVATIVES AS MODULATORS OF THE 5-HT2A RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2008-03-06 | — | — | WO | disclosed |