Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4796153 | 0.82 | MAPT (0.43) | MAPTGAARAB9APKMHTT | |
| SCHEMBL6987618 | 0.80 | MAPT (0.54) | MAPTGAARAB9AHTTL3MBTL1 | |
| SCHEMBL6979379 | 0.79 | MAPT (0.55) | MAPTGAARAB9AHTTL3MBTL1 | |
| SCHEMBL4782514 | 0.78 | FNTA (0.39) | MAPTRAB9AL3MBTL1LMNAPOLB | |
| SCHEMBL4727973 | 0.77 | MAPT (0.53) | MAPTGAARAB9AHTTL3MBTL1 | |
| SCHEMBL26688263 | 0.77 | MAPT (0.53) | MAPTGAARAB9AHTTL3MBTL1 | |
| SCHEMBL6985505 | 0.76 | MAPT (0.73) | MAPTGAARAB9AHTTL3MBTL1 | |
| SCHEMBL6983248 | 0.75 | MAPT (0.51) | MAPTGAARAB9AHTTL3MBTL1 | |
| SCHEMBL4795025 | 0.72 | CHEK1 (0.40) | MAPTRAB9APKMHTTL3MBTL1 | |
| SCHEMBL2249264 | 0.72 | POLB (0.52) | MAPTGAARAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008027483-A1 | BENZOFURAN DERIVATIVES AS MODULATORS OF THE 5-HT2A RECEPTOR | ARENA PHARMACEUTICALS, INC. (US) | 2008-03-06 | — | — | WO | disclosed |