Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | DDO | Q99489 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4803301 | 0.84 | SRD5A2 (0.51) | CASP3SENP8SENP7SENP6F2 | |
| Hydroxyamine SCHEMBL5618267 | 0.83 | MRGPRX4 (0.46) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL5132984 | 0.83 | HDAC6 (0.51) | PIN1ITK | |
| Hydroxyamine SCHEMBL4807777 | 0.83 | CASP3 (0.50) | CASP3SENP8SENP7SENP6F2 | |
| SCHEMBL6950558 | 0.83 | ITK (0.39) | NR4A2CASP3SENP8SENP7SENP6 | |
| Hydroxyamine SCHEMBL5144256 | 0.82 | KDM4A (0.50) | CASP3SENP8SENP7SENP6F2 | |
| Hydroxyamine SCHEMBL4796509 | 0.81 | LMNA (0.53) | TAS2R14 | |
| SCHEMBL6990951 | 0.80 | DAO (0.49) | F2PIN1KDM4EDAODDO | |
| Hydroxyamine SCHEMBL4795956 | 0.79 | PDE5A (0.52) | NR4A2CASP3SENP8SENP7SENP6 | |
| SCHEMBL7487224 | 0.77 | MAP2K4 (0.47) | PIN1DAODDO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061160-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2008-05-22 | — | — | WO | claimed |