Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL5144256 | 0.84 | KDM4A (0.50) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL4796231 | 0.84 | HDAC6 (0.54) | CHEK2NR1H4PIN1ITK | |
| Hydroxyamine SCHEMBL4796191 | 0.83 | NR4A2 (0.46) | CASP3SENP8SENP7SENP6CHEK2 | |
| Hydroxyamine SCHEMBL4795956 | 0.82 | PDE5A (0.52) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL4803301 | 0.80 | SRD5A2 (0.51) | CASP3SENP8SENP7SENP6F2 | |
| Hydroxyamine SCHEMBL5618267 | 0.80 | MRGPRX4 (0.46) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL6991892 | 0.79 | LOXL2 (0.55) | — | |
| Hydroxyamine SCHEMBL4796509 | 0.78 | LMNA (0.53) | MEN1KMT2AHTTACHEMRGPRX4 | |
| Hydroxyamine SCHEMBL4802770 | 0.76 | TUBB4A (0.41) | CASP3SENP8SENP7SENP6HTT | |
| SCHEMBL977626 | 0.75 | F2 (0.70) | CASP3SENP8SENP7SENP6F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061160-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |