Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650362 | 0.83 | PARP1 (0.44) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL11824255 | 0.77 | MAPK1 (0.41) | ALDH1A1KDM4EHPGDLMNAGAA | |
| SCHEMBL23048476 | 0.76 | NPC1 (0.47) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL4801967 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDCNR2SMN1; SMN2 | |
| SCHEMBL19692682 | 0.72 | PARP1 (0.34) | ALDH1A1PARP1 | |
| SCHEMBL6749423 | 0.72 | BCL2L1 (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL19314096 | 0.71 | GABRA1 (0.38) | LMNADRD2 | |
| SCHEMBL10676767 | 0.70 | HSD17B10 (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL28966834 | 0.70 | AKR1B1 (0.42) | KDM4EHPGDMAPTTDP1 | |
| SCHEMBL30201955 | 0.70 | AKR1B1 (0.42) | KDM4EHPGDMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361789-B1 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis | AMGEN INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361789-B1 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis | AMGEN INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361789-B1 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis | AMGEN INC. (US) | 2008-04-22 | — | — | US | disclosed |