Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753321 | 0.84 | ALDH1A1 (0.40) | ALDH1A1HPGDKDM4EMAPTALOX15 | |
| SCHEMBL24725708 | 0.83 | ALDH1A1 (0.36) | ALDH1A1HPGDKDM4EALOX15PARP1 | |
| SCHEMBL13980589 | 0.82 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EDRD2GAA | |
| SCHEMBL5751732 | 0.82 | TRPA1 (0.48) | ALDH1A1KDM4EDRD2KMT2A | |
| SCHEMBL13740090 | 0.80 | PARP1 (0.32) | PARP1 | |
| SCHEMBL28426457 | 0.76 | CHRNB2 (0.43) | ALDH1A1GAASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL18602231 | 0.76 | NPC1 (0.47) | ALDH1A1HPGDKDM4EGAAMAPK1 | |
| SCHEMBL5749754 | 0.75 | ALDH1A1 (0.38) | ALDH1A1HPGDKDM4EMAPTALOX15 | |
| SCHEMBL5753051 | 0.73 | CXCR5 (0.39) | ALDH1A1HPGDKDM4EGAAMAPT | |
| SCHEMBL24479743 | 0.73 | TRPA1 (0.46) | ALDH1A1HPGDKDM4EDRD2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361789-B1 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis | AMGEN INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361789-B1 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis | AMGEN INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361789-B1 | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis | AMGEN INC. (US) | 2008-04-22 | — | — | US | disclosed |