Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | PDE5A | O76074 | 5/20 | 0.50 |
| ▸ | PDE1A | P54750 | 2/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623653 | 0.84 | PDE5A (0.43) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL9646522 | 0.83 | KDM4E (0.44) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL4796596 | 0.82 | PDE1A (0.46) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL6234430 | 0.79 | PDE5A (0.64) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL5646 | 0.76 | PDE2A (0.61) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL3110928 | 0.76 | PNP (0.48) | MEN1KMT2APDE5ATSHRALDH1A1 | |
| SCHEMBL19583186 | 0.75 | KDM4E (0.43) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL272517 | 0.73 | KDM4E (0.41) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL9645631 | 0.72 | ADORA2A (0.40) | MEN1KMT2APDE5APDE1APDE1B | |
| SCHEMBL2053839 | 0.72 | PDE5A (0.42) | MEN1KMT2APDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968204-A1 | PHOSPHODIESTERASE INHIBITOR TREATMENT | Henkin, Robert I. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2903619-A1 | PHOSPHODIESTERASE INHIBITORS FOR TREATING TASTE AND SMELL DISORDERS | Henkin, Robert I. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014143453-A1 | PHOSPHODIESTERASE INHIBITOR TREATMENT | HENKIN ROBERT I (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014055801-A1 | PHOSPHODIESTERASE INHIBITORS FOR TREATING TASTE AND SMELL DISORDERS | HENKIN ROBERT I (US) | 2014-04-10 | — | — | WO | disclosed |
| EP-1267862-A2 | METHODS AND COMPOSITIONS FOR IMPROVING SLEEP | Cellegy Canada Inc. (CA) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001062290-A2 | METHODS AND COMPOSITIONS FOR IMPROVING SLEEP | CELLEGY CANADA INC. (CA) | 2001-08-30 | — | — | WO | disclosed |