Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.45 |
| ▸ | BRD2 | P25440 | 2/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23797830 | 0.88 | HTT (0.42) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4623658 | 0.87 | PDE4A (0.39) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL3110932 | 0.84 | PDE1A (0.53) | BRD4MEN1KMT2AHPGDPDE2A | |
| SCHEMBL5647 | 0.84 | ADORA2A (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4623458 | 0.82 | PDE4A (0.63) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4626797 | 0.80 | BRD4 (0.65) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL652922 | 0.78 | MAPK1 (0.39) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4621714 | 0.78 | PDE4A (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL27501339 | 0.74 | BRD4 (0.58) | BRD4BRD2BRD3BRDTMEN1 | |
| SCHEMBL6251096 | 0.73 | PDE4A (0.64) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008028250-A1 | THERAPEUTIC AGENTS, TARGETS AND DIAGNOSTICS | AUTOGEN RESEARCH PTY LTD (AU) | 2008-03-13 | — | — | WO | disclosed |
| EP-0101681-A4 | Antibody to a mediator activity composition and its use in a pharmaceutical composition. | UNIV ROCKEFELLER (US) | 1985-06-06 | — | — | EP | disclosed |
| EP-0101681-A1 | Antibody to a mediator activity composition and its use in a pharmaceutical composition. | UNIV ROCKEFELLER (US) | 1984-03-07 | — | — | EP | disclosed |
| WO-1983000930-A1 | LIPOPROTEIN LIPASE SUPPRESSION BY ENDOTOXIN-INDUCE MEDIATOR (SHOCK ASSAY) | UNIV ROCKEFELLER (US) | 1983-03-17 | — | — | WO | disclosed |