Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479774 | 0.96 | CHEK1 (0.36) | CHEK1AURKBDAPK3PRKD3MAP4K4 | |
| SCHEMBL3709540 | 0.93 | LMNA (0.38) | CHEK1AURKBDAPK3PRKD3MAP4K4 | |
| SCHEMBL479369 | 0.92 | AURKA (0.37) | CHEK1AURKBDAPK3PRKD3MAP4K4 | |
| SCHEMBL479345 | 0.89 | LMNA (0.40) | CHEK1AURKBDAPK3PRKD3MAP4K4 | |
| SCHEMBL479687 | 0.87 | TGM2 (0.34) | AURKBPDGFRBPDPK1AURKARAF1 | |
| SCHEMBL2573040 | 0.86 | SRC (0.38) | CHEK1AURKBDAPK3PRKD3MAP4K4 | |
| SCHEMBL479357 | 0.86 | SRC (0.38) | CHEK1AURKBDAPK3PRKD3MAP4K4 | |
| SCHEMBL479775 | 0.84 | TGM2 (0.33) | AURKBPDGFRBPDGFRAKDRPDPK1 | |
| SCHEMBL16752524 | 0.83 | AURKA (0.38) | CHEK1AURKBPDGFRBPDGFRAPDPK1 | |
| SCHEMBL16752525 | 0.83 | AURKA (0.38) | CHEK1AURKBPDGFRBPDGFRAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411034-A1 | PROMOTION OF NEURONAL INTEGRATION IN NEURAL STEM CELL GRAFTS | Life & Brain GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108665-A1 | PROMOTION OF NEURONAL INTEGRATION IN NEURAL STEM CELL GRAFTS | LIFE & BRAIN GMBH (DE) | 2010-09-30 | — | — | WO | disclosed |