SCHEMBL47974

SCHEMBL47974

O=[C]OCc1ccc(Cl)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.58
NR4A2 P43354 2/20 0.47
CYP1A2 P05177 3/20 0.47
CYP2C9 P11712 3/20 0.47
CYP2C19 P33261 3/20 0.47
CYP3A4 P08684 2/20 0.47
MAPK1 P28482 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
NR4A1 P22736 1/20 0.44
NR4A3 Q92570 1/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
CYP2D6 P10635 2/20 0.42
MAPT P10636 1/20 0.42
RECQL P46063 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6943180 0.85 IDO1 (0.40) IDO1NR4A2CYP1A2CYP2C9CYP2C19
SCHEMBL11267922 0.81 IDO1 (0.46) IDO1NR4A2CYP1A2CYP2C9CYP2C19
SCHEMBL6150174 0.81 ALDH1A1 (0.46) IDO1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL10372923 0.81 IDO1 (0.58) IDO1NR4A2CYP1A2CYP2C9CYP2C19
SCHEMBL29984975 0.77 IDO1 (0.69) IDO1NR4A2CYP1A2CYP2C9CYP2C19
SCHEMBL165560 0.77 IDO1 (0.69) IDO1NR4A2CYP1A2CYP2C9CYP2C19
SCHEMBL7888003 0.77 IDO1 (0.69) IDO1NR4A2CYP1A2CYP2C9CYP2C19
Lysine SCHEMBL9179970 0.77 GSR (0.46) IDO1NR4A2L3MBTL1NR4A1NR4A3
SCHEMBL8916749 0.77 IDO1 (0.53) IDO1NR4A2CYP1A2CYP2C9CYP2C19
SCHEMBL5535584 0.76 NR4A2 (0.38) IDO1NR4A2L3MBTL1NR4A1NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2185 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023151188-A1 GREEN SYNTHESIS METHOD OF ANTIVIRAL DRUG INTERMEDIATE 上海皓元医药股份有限公司 2023-08-17 WO claimed
CN-114671798-B Green synthesis method of antiviral drug intermediate 上海皓元医药股份有限公司 2022-08-16 CN claimed
CN-114671798-A Green synthesis method of antiviral drug intermediate 上海皓元医药股份有限公司 2022-06-28 CN claimed
EP-2788353-B1 CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS Clarity Pharmaceuticals Ltd (AU) 2022-05-18 EP claimed
EP-3053944-B1 METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END, POLYMERIZATION INITIATOR FOR USE IN THE SAME, AND ALCOHOL COMPOUND AS RAW MATERIAL FOR THE POLYMERIZATION INITIATOR SHINETSU CHEMICAL CO (JP) 2021-10-06 EP claimed
CN-108147972-B Preparation method of vipatavir intermediate and analogue thereof 成都西岭源药业有限公司 2020-07-10 CN claimed
CN-105658658-B Cytidine-5-formyl amine-modified polynucleotide composition and its correlation technique 私募蛋白质体公司 2019-11-05 CN claimed
CN-110343117-A The preparation method of artemisinin derivative 中国科学院上海药物研究所 2019-10-18 CN claimed
US-10239908-B2 Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto SOMALOGIC, INC. (US) 2019-03-26 US claimed
US-20180201641-A1 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto SOMALOGIC OPERATING CO. INC. 2018-07-19 US claimed
US-4537720-A N-substituted-2-(R)-(sulfinic acid)-3-(S)-(acylamino)-4-oxo-azetidines and process ELI LILLY AND COMPANY (US) 1985-08-27 US claimed
EP-0134986-A2 Biologically active heptapeptides, agents thereof and their use FARMITALIA CARLO ERBA S.r.l. (IT) 1985-03-27 EP claimed
US-4491541-A Peptides FARMITALIA CARLO ERBA 1985-01-01 US claimed
US-4474765-A Biologically active peptides FARMITALIA CARLO ERBA S.P.A. (IT) 1984-10-02 US claimed
US-4242238-A OLIGO- AND RESIN PEPTIDES, ACTH(1-28) ARMOUR AND COMPANY (US) 1980-12-30 US claimed
US-4148788-A Synthesis of thymosin α1 HOFFMANN-LA ROCHE INC. (US) 1979-04-10 US claimed
US-4130514-A RESIN, ADRENOCORTICOTROPIC ACTIVITY ARMOUR PHARMACEUTICAL COMPANY (US) 1978-12-19 US claimed
US-4105602-A SYNTHESIS OF PEPTIDES WITH PARATHYROID HORMONE ACTIVITY ARMOUR PHARMACEUTICAL COMPANY (US) 1978-08-08 US claimed
US-4089821-A Synthesis of peptide amides ARMOUR PHARMACEUTICAL COMPANY (US) 1978-05-16 US claimed
US-4055524-A RESIN PEPTIDE ARMOUR PHARMACEUTICAL COMPANY (US) 1977-10-25 US claimed