Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.68 |
| ▸ | RELA | Q04206 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 5/20 | 0.55 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804942 | 0.83 | APP (0.68) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL27897630 | 0.83 | AHR (0.58) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL2248827 | 0.81 | RAB9A (1.00) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL4809936 | 0.81 | AHR (0.60) | NFKB1RAB9ANFKB2RELATP53 | |
| SCHEMBL13806234 | 0.80 | APP (0.77) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL11188660 | 0.80 | AHR (0.56) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL5416199 | 0.78 | TP53 (0.77) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL19174390 | 0.77 | SMN1; SMN2 (0.58) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL19149020 | 0.77 | AHR (0.49) | NFKB1RAB9ANFKB2RELALMNA | |
| SCHEMBL19149498 | 0.77 | KDM4E (0.65) | NFKB1RAB9ANFKB2RELATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384966-B2 | 2-arylbenzothiazole derivatives | PHARMINXO LIMITED (GB) | 2008-06-10 | — | — | US | disclosed |
| US-20060063816-A1 | 2-Arylbenzothiazole derivatives | STEVENS MALCOLM F G | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063816-A1 | 2-Arylbenzothiazole derivatives | CX3CR1, HCN2, CYBB | NFKB1 2720/4885RAB9A 1419/4885NFKB2 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.