Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802020 | 0.87 | TRPM8 (0.43) | TRPM8POLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6742389 | 0.79 | TRPM8 (0.40) | TRPM8POLBALDH1A1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6740643 | 0.76 | ITGB1 (0.40) | TRPM8ALDH1A1ITGB1ITGA5ITGB3 | |
| SCHEMBL7669220 | 0.75 | JAK2 (0.46) | POLBALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL7484451 | 0.70 | MAPT (0.34) | TRPM8POLBMAPTSMN1; SMN2RAB9A | |
| SCHEMBL6451838 | 0.67 | SYK (0.36) | — | |
| SCHEMBL1569639 | 0.66 | HDAC6 (0.40) | — | |
| SCHEMBL6176392 | 0.65 | AOC3 (0.36) | JAK2 | |
| SCHEMBL12176776 | 0.64 | TSHR (0.40) | KMT2AMEN1 | |
| SCHEMBL792607 | 0.64 | JAK2 (0.42) | TRPM8ALDH1A1KMT2AMEN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361679-B2 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2008-04-22 | — | — | US | disclosed |
| US-7361679-B2 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2008-04-22 | — | — | US | disclosed |
| US-7361679-B2 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2008-04-22 | — | — | US | disclosed |
| US-20040259908-A1 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1084119-B1 | AROMATIC AMINE DERIVATIVES AS PHARMACEUTICAL AGENTS | CELLTECH THERAPEUTICS LTD (GB) | 2004-09-08 | — | — | EP | disclosed |
| EP-1426360-A1 | 2-PHENYL-3-HETEROARYLPROPIONIC ACID DERIVATIVE OR SALT THEREOF AND MEDICINE CONTAINING THE SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2004-06-09 | — | — | EP | disclosed |
| US-6369229-B1 | IMMUNOLOGY AND ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 2002-04-09 | — | — | US | disclosed |
| US-6110945-A | AN ANTIINFLAMMATORY AGENT INHIBITING THE BINDING OF INTEGRINS TO THEIR LIGANDS; IN THE PROPHYLAXIS FOR TREATING IMMUNE OR INFLAMMATORY DISORDERS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259908-A1 | 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same | LPAR4, LPAR2, LPAR1 | TRPM8 1038/4885POLB 4373/4885ALDH1A1 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.