SCHEMBL6742389

SCHEMBL6742389

O=C(c1c(Cl)cccc1Cl)N(C(=O)c1c(Cl)cccc1Cl)c1ccc(I)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.40
ALDH1A1 P00352 4/20 0.38
KMT2A Q03164 4/20 0.37
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 1/20 0.37
POLB P06746 1/20 0.35
MEN1 O00255 3/20 0.34
HPGD P15428 2/20 0.34
USP2 O75604 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HSD17B10 Q99714 1/20 0.34
GAA P10253 1/20 0.33
GPBAR1 Q8TDU6 1/20 0.33
HAVCR2 Q8TDQ0 1/20 0.33
JAK2 O60674 3/20 0.33
TYK2 P29597 3/20 0.33
JAK1 P23458 2/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4798192 0.79 TRPM8 (0.44) TRPM8ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL4802020 0.78 TRPM8 (0.43) TRPM8ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL7754454 0.71 ALDH1A1 (0.39) TRPM8ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL6744434 0.70 RAB9A (0.50) ALDH1A1MAPTNPC1RAB9ANPSR1
SCHEMBL7484451 0.69 MAPT (0.34) TRPM8MAPTSMN1; SMN2RAB9APOLB
SCHEMBL792607 0.66 JAK2 (0.42) TRPM8ALDH1A1KMT2AMEN1GAA
SCHEMBL7760757 0.65 RORC (0.41) JAK2TYK2JAK1
SCHEMBL6230454 0.65 KMT2A (0.45) TRPM8ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL29034050 0.63 ALDH1A1 (0.37) TRPM8ALDH1A1KMT2ANPC1POLB
SCHEMBL11280642 0.62 SMN1; SMN2 (0.49) KMT2AMAPTSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6685617-B1 4-(((-1-CARBOXY-2-(4-((2,6-DICHLOROBENZOYL)AMINE)PHENYL)ETHYL) AMINO)CARBONYL)-3-OXO-3-THIAZOLIDINEBUTANOIC ACID, USED AS ANTAGONISTS FOR CELLULAR ADHESION MOLECULES, AND ADMINISTERED AS ANTIINFLAMMATORY AGENTS PHARMACIA & UPJOHN COMPANY 2004-02-03 US disclosed
EP-1089989-A1 INHIBITORS OF ALPHA4BETA1 MEDIATED CELL ADHESION PHARMACIA & UPJOHN COMPANY (US) 2001-04-11 EP disclosed
WO-1999067230-A1 INHIBITORS OF α4β1 MEDIATED CELL ADHESION PHARMACIA & UPJOHN COMPANY (US) 1999-12-29 WO disclosed