Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.85 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.85 |
| ▸ | F10 | P00742 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CCR2 | P41597 | 4/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302610 | 0.91 | NOD2 (0.84) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL6307843 | 0.90 | NOD2 (0.74) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL12948823 | 0.90 | NOD2 (0.82) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL5421098 | 0.90 | NOD2 (0.82) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL6706704 | 0.90 | NOD2 (0.82) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL6858374 | 0.89 | NOD2 (0.80) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL8686408 | 0.88 | SMN1; SMN2 (0.68) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL5213582 | 0.88 | NOD2 (0.78) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL1503984 | 0.87 | NOD2 (0.67) | NOD2NOD1F10KMT2AMEN1 | |
| SCHEMBL4198841 | 0.87 | NOD2 (0.77) | NOD2NOD1F10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
| US-20080269514-A1 | Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines With Copper Reagents | SALTIGO GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| US-7342039-B2 | Substituted indole oximes | WYETH (US) | 2008-03-11 | — | — | US | disclosed |
| CN-1882323-A | Substituted benzofuran oximes | WYETH CORP (US) | 2006-12-20 | — | — | CN | disclosed |
| EP-1667670-A1 | 4-(1H-INDOL-3-YL-METHYLIDENEAMINOXY-PROPOXY)-BENZOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS PAI-1 INHIBITORS FOR THE TREATMENT OF IMPAIREMENT OF THE FIBRINOLYTIC SYSTEM AND OF THROMBISIS | Wyeth (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050119326-A1 | Substituted aryloximes | WYETH (US) | 2005-06-02 | — | — | US | disclosed |
| WO-2005030192-A1 | 4- (1H-INDOL-3-YL-METHYLIDENEAMINOXY-PROPOXY) -BENZIOC ACID DERIVATIVES AND RELATED COMPOUNDS AS PAI-1 INHIBITORS FOR THE TREATMENT OF IMPAIRMENT OF THE FIBRINOLYTIC SYSTEM AND OF THROMBISIS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269514-A1 | Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines With Copper Reagents | SLC39A14, MAL2, AHR | NOD2 1366/4885NOD1 3815/4885F10 1770/4885 |
| US-20050119326-A1 | Substituted aryloximes | IDO2, TDO2, IDO1 | NOD2 889/4885NOD1 2871/4885F10 4259/4885 |
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | APP, PSEN2, PSEN1 | NOD2 1296/4885NOD1 1772/4885F10 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.