Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | CRHBP | P24387 | 1/20 | 0.68 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.68 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.67 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | F10 | P00742 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962292 | 0.90 | NOD2 (0.69) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL4798323 | 0.88 | NOD2 (0.85) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL3963612 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL6752352 | 0.86 | KDM4E (0.71) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL1422759 | 0.86 | MTNR1A (0.65) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL30489155 | 0.85 | KDM4E (0.73) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL4215637 | 0.85 | KDM4E (0.70) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL13742183 | 0.85 | KDM4E (0.70) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL18322286 | 0.85 | KDM4E (0.73) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 | |
| SCHEMBL21822198 | 0.85 | TSHR (0.53) | SMN1; SMN2KDM4ECRHBPCRHR2NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |