Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 18/20 | 0.58 |
| ▸ | CTSL | P07711 | 10/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798541 | 1.00 | CTSS (0.58) | CTSSCTSLCTSKSMN1; SMN2NPY5R | |
| SCHEMBL4796802 | 0.87 | CTSS (0.57) | CTSSCTSLCTSKSMN1; SMN2 | |
| SCHEMBL4801486 | 0.87 | CTSS (0.57) | CTSSCTSLCTSKSMN1; SMN2 | |
| SCHEMBL4801471 | 0.87 | CTSS (0.57) | CTSSCTSLCTSKSMN1; SMN2 | |
| SCHEMBL4796787 | 0.87 | CTSS (0.57) | CTSSCTSLCTSKSMN1; SMN2 | |
| SCHEMBL4800441 | 0.87 | CTSS (0.59) | CTSSCTSLCTSK | |
| SCHEMBL4800466 | 0.87 | CTSS (0.59) | CTSSCTSLCTSK | |
| SCHEMBL4796097 | 0.86 | CTSS (0.61) | CTSSCTSLCTSK | |
| SCHEMBL4799197 | 0.86 | CTSS (0.58) | CTSSCTSLCTSKSMN1; SMN2 | |
| SCHEMBL4796107 | 0.86 | CTSS (0.61) | CTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | claimed |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | disclosed |
| US-7384970-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2008-06-10 | — | — | US | disclosed |
| US-20040248887-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248887-A1 | Inhibitors of cathepsin S | CTSS, CTSB, CTSZ | CTSS 1/4885CTSL 11/4885CTSK 9/4885 |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | CTSS, CTSB, CTSZ | CTSS 1/4885CTSL 11/4885CTSK 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.