Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 7/20 | 0.75 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.75 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.75 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4803367 | 0.94 | SCN1A (0.66) | SCN1ASCN5ASCN9APLD1ABCB1 | |
| SCHEMBL4806633 | 0.94 | SCN1A (0.66) | SCN1ASCN5ASCN9APLD1CCR1 | |
| SCHEMBL4800272 | 0.90 | SCN1A (0.69) | SCN1ASCN5ASCN9APLD1ABCB1 | |
| Hydrochloric Acid SCHEMBL4808473 | 0.89 | SCN1A (0.68) | SCN1ASCN5ASCN9APLD1ABCB1 | |
| Hydrochloric Acid SCHEMBL4806574 | 0.83 | OPRL1 (0.61) | SCN1ASCN5ASCN9APLD1OPRL1 | |
| SCHEMBL4805216 | 0.79 | PLD2 (0.59) | SCN1ASCN5ASCN9APLD1OPRL1 | |
| SCHEMBL4807271 | 0.78 | OPRL1 (0.67) | PLD1OPRL1 | |
| SCHEMBL4806019 | 0.78 | OPRL1 (0.63) | PLD1OPRL1 | |
| SCHEMBL4804251 | 0.77 | OPRL1 (0.52) | SCN1ASCN5ASCN9APLD1HSD11B1 | |
| SCHEMBL7696937 | 0.77 | OPRL1 (0.52) | SCN1ASCN5ASCN9APLD1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | claimed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | claimed |
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | disclosed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | disclosed |
| EP-1373248-A1 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | AstraZeneca AB (SE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002074763-A9 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002074763-A1 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |