Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4796818 | 0.88 | CNR1 (0.37) | CNR1CYP2D6TSHRCYP3A4HSD11B1 | |
| SCHEMBL4797207 | 0.87 | ITGAL (0.39) | — | |
| SCHEMBL4800640 | 0.87 | CNR1 (0.37) | CNR1CYP2D6TSHRCYP3A4HSD11B1 | |
| SCHEMBL4799595 | 0.86 | CYP3A4 (0.37) | CNR1CYP2D6TSHRCYP3A4HSD11B1 | |
| SCHEMBL4796233 | 0.86 | CNR1 (0.39) | CNR1CYP2D6TSHRCYP3A4HSD11B1 | |
| SCHEMBL4797065 | 0.82 | TRPV4 (0.35) | CNR1 | |
| SCHEMBL4797278 | 0.78 | CNR1 (0.35) | CNR1CYP2D6TSHRCYP3A4MCHR1 | |
| SCHEMBL4845276 | 0.74 | ITGAL (0.42) | CNR1HSD11B1METAP2 | |
| SCHEMBL4849035 | 0.73 | HSD11B1 (0.39) | CNR1CYP2D6TSHRCYP3A4HSD11B1 | |
| SCHEMBL4637430 | 0.72 | TRPV4 (0.35) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375237-B2 | Pyrrolizine compounds useful as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-20 | — | — | US | claimed |
| US-20060052434-A1 | Pyrrolizine compounds useful as anti-inflammatory agents | CEREP S.A. (FR) | 2006-03-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052434-A1 | Pyrrolizine compounds useful as anti-inflammatory agents | NFKBIA, TNF, NFKB1 | CNR1 420/4885CYP2D6 1109/4885TSHR 3736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.