Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 6/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467490 | 0.75 | ALDH1A1 (0.41) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4801478 | 0.73 | TEK (0.45) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4479617 | 0.72 | ALDH1A1 (0.40) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4479614 | 0.72 | ALDH1A1 (0.40) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4803560 | 0.69 | SELE (0.38) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9199015 | 0.68 | ALDH1A1 (0.39) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL6837677 | 0.67 | ALDH1A1 (0.43) | ALDH1A1LMNAHPGDTP53 | |
| SCHEMBL4472087 | 0.67 | ALDH1A1 (0.55) | ALDH1A1LMNAHTTKMT2ACYP1A2 | |
| SCHEMBL5065447 | 0.62 | ALDH1A1 (0.50) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL6250372 | 0.62 | ALDH1A1 (1.00) | ALDH1A1LMNACSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427616-B2 | Condensed pyridines and pyrimidines with tie2 (TEK) activity | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | TIE1, TEK, KDR | ALDH1A1 2177/4885LMNA 3041/4885CSNK2A2 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.