Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800151 | 0.88 | GRM1 (0.51) | MAOAGRM1NPC1RAB9AALDH1A1 | |
| SCHEMBL4800549 | 0.83 | NPC1 (0.54) | GRM1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4802240 | 0.81 | RAB9A (0.47) | MAOAGRM1NPC1RAB9AALDH1A1 | |
| SCHEMBL3340949 | 0.77 | MAPT (0.53) | MAOARAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL4798176 | 0.70 | GRM1 (0.55) | GRM1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4801351 | 0.70 | GRM1 (0.57) | GRM1NPC1RAB9AALDH1A1GRM5 | |
| SCHEMBL3341175 | 0.69 | GRM1 (0.59) | GRM1NPC1RAB9AALDH1A1GRM5 | |
| SCHEMBL127262 | 0.67 | RAB9A (0.54) | MAOANPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4800674 | 0.66 | GRM1 (0.57) | GRM1NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4782519 | 0.66 | RAB9A (0.74) | MAOAGRM1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |