Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4797456 | 0.85 | GRM1 (0.48) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4800151 | 0.85 | GRM1 (0.51) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4782600 | 0.83 | GRM1 (0.51) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4800549 | 0.82 | NPC1 (0.54) | RAB9ANPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4801252 | 0.81 | MAOA (0.39) | RAB9ANPC1MAPTKDM4EALDH1A1 | |
| SCHEMBL4780726 | 0.80 | MAPT (0.53) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3338686 | 0.76 | MAPT (0.56) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4798176 | 0.75 | GRM1 (0.55) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4845367 | 0.74 | RAB9A (0.45) | RAB9ANPC1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4799024 | 0.71 | KMT2A (0.53) | RAB9ANPC1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |