Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 9/20 | 1.00 |
| ▸ | HTR6 | P50406 | 11/20 | 0.75 |
| ▸ | HTR1A | P08908 | 7/20 | 0.75 |
| ▸ | HTR1D | P28221 | 7/20 | 0.75 |
| ▸ | HTR1B | P28222 | 7/20 | 0.75 |
| ▸ | DRD2 | P14416 | 6/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.75 |
| ▸ | DRD3 | P35462 | 6/20 | 0.75 |
| ▸ | HTR2C | P28335 | 5/20 | 0.75 |
| ▸ | HTR7 | P34969 | 5/20 | 0.75 |
| ▸ | HTR4 | Q13639 | 5/20 | 0.75 |
| ▸ | HTR2A | P28223 | 5/20 | 0.75 |
| ▸ | DRD1 | P21728 | 1/20 | 0.75 |
| ▸ | DRD4 | P21917 | 1/20 | 0.75 |
| ▸ | HTR2B | P41595 | 5/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801555 | 1.00 | GHSR (1.00) | GHSRHTR6HTR1AHTR1DHTR1B | |
| SCHEMBL29386932 | 0.86 | HTR6 (1.00) | GHSRHTR6HTR1AHTR1DHTR1B | |
| SCHEMBL194700 | 0.86 | HTR6 (1.00) | GHSRHTR6HTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6977773 | 0.85 | HTR6 (1.00) | GHSRHTR6HTR1AHTR1DHTR1B | |
| SCHEMBL1136525 | 0.85 | HTR6 (1.00) | GHSRHTR6HTR1AHTR1DHTR1B | |
| SCHEMBL29496144 | 0.85 | HTR6 (1.00) | GHSRHTR6HTR1AHTR1DHTR1B | |
| SCHEMBL4801239 | 0.84 | GHSR (0.81) | GHSRHTR6HTR1AHTR1DHTR1B | |
| SCHEMBL4796477 | 0.83 | GHSR (0.73) | GHSR | |
| SCHEMBL4796467 | 0.83 | GHSR (0.73) | GHSR | |
| SCHEMBL7197257 | 0.82 | HTR6 (0.77) | GHSRHTR6HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381728-B2 | Piperazine derivatives useful for the treatment of gastrointestinal disorders | GLAXO GROUP LIMITED (GB) | 2008-06-03 | — | — | US | claimed |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GLAXO GROUP LIMITED | 2007-11-08 | — | — | US | claimed |
| US-7381728-B2 | Piperazine derivatives useful for the treatment of gastrointestinal disorders | GLAXO GROUP LIMITED (GB) | 2008-06-03 | — | — | US | disclosed |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GLAXO GROUP LIMITED | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GHSR, GHRHR, GIPR | GHSR 1/4885HTR6 313/4885HTR1A 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.