Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5064708 | 0.81 | CYP1A2 (0.43) | CYP1A2CYP2C19MKNK1ALDH1A1 | |
| SCHEMBL16024218 | 0.66 | MKNK1 (0.45) | MKNK1 | |
| SCHEMBL6840358 | 0.63 | CYP1A2 (0.46) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL5639344 | 0.63 | CYP1A2 (0.43) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL5637413 | 0.62 | CYP1A2 (0.45) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL8316849 | 0.61 | ALDH1A1 (0.46) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL743224 | 0.61 | MAPT (0.47) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL13593122 | 0.61 | CYP1A2 (0.44) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL27002200 | 0.60 | CA2 (0.36) | CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL28758323 | 0.60 | ALDH1A1 (0.42) | CYP1A2CYP2C19ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427616-B2 | Condensed pyridines and pyrimidines with tie2 (TEK) activity | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | TIE1, TEK, KDR | CYP1A2 1052/4885CYP2C19 1787/4885MKNK1 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.