Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.42 |
| ▸ | HPGDS | O60760 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993255 | 0.91 | ALOX5AP (0.56) | ALOX5APHDAC1HDAC6HDAC5HPGDS | |
| SCHEMBL709386 | 0.86 | ALOX5AP (0.56) | ALOX5APHDAC1HDAC6HDAC5HPGDS | |
| SCHEMBL706788 | 0.86 | ALOX5AP (0.56) | ALOX5APHDAC1HDAC6HDAC5HPGDS | |
| SCHEMBL480426 | 0.84 | ALOX5AP (0.47) | ALOX5APHDAC1HDAC6HDAC5HPGDS | |
| SCHEMBL480001 | 0.83 | ALOX5AP (0.57) | ALOX5APHDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL709117 | 0.83 | ALOX5AP (0.58) | ALOX5APHDAC1HDAC6HDAC5ADAMTS4 | |
| SCHEMBL3003924 | 0.82 | ALOX5AP (0.49) | ALOX5APHDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL9924137 | 0.82 | ALOX5AP (0.53) | ALOX5APHDAC1HDAC6HDAC5HPGDS | |
| SCHEMBL480213 | 0.81 | ALOX5AP (0.54) | ALOX5AP | |
| SCHEMBL3000129 | 0.81 | AOC3 (0.43) | ALOX5APHDAC1HDAC6HDAC5HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | claimed |
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | claimed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | claimed |
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
| EP-2064204-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008030369-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALOX5AP 14/4885HDAC1 1862/4885HDAC6 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.