Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808827 | 0.91 | CYP3A4 (0.48) | CYP3A4KCNH2CYP2C9CYP2C19MTNR1B | |
| SCHEMBL4807122 | 0.89 | CYP3A4 (0.47) | CYP3A4KCNH2CYP2C9CYP2C19MTNR1B | |
| SCHEMBL4805650 | 0.86 | CYP3A4 (0.47) | CYP3A4KCNH2MTNR1BAPOBEC3GMAPK1 | |
| SCHEMBL4808423 | 0.84 | APOBEC3G (0.42) | CYP3A4KCNH2MTNR1BAPOBEC3GMAPK1 | |
| SCHEMBL4805444 | 0.81 | CYP3A4 (0.45) | CYP3A4KCNH2CYP2C9CYP2C19MTNR1B | |
| SCHEMBL5411461 | 0.80 | APOBEC3G (0.40) | CYP3A4CYP2C9CYP2C19MTNR1BAPOBEC3G | |
| SCHEMBL4799252 | 0.80 | APOBEC3G (0.45) | CYP3A4KCNH2MTNR1BAPOBEC3GMAPK1 | |
| SCHEMBL14040349 | 0.80 | CYP3A4 (0.56) | CYP3A4KCNH2CYP2C9CYP2C19APOBEC3G | |
| SCHEMBL4809760 | 0.80 | CYP3A4 (0.51) | CYP3A4KCNH2CYP2C9CYP2C19MTNR1B | |
| SCHEMBL4800446 | 0.80 | CYP3A4 (0.76) | CYP3A4KCNH2CYP2C9CYP2C19MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348345-B2 | Nonnucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | DUNN JAMES P | 2007-08-02 | — | — | US | disclosed |
| US-7208509-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | RRM2, RRM2B, SAMHD1 | CYP3A4 438/4885KCNH2 3216/4885CYP2C9 1755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.