Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808827 | 0.89 | CYP3A4 (0.48) | CYP3A4FNTAFNTBPGGT1BP2RX3 | |
| SCHEMBL4805105 | 0.85 | APOBEC3G (0.41) | CYP3A4FNTAFNTBPGGT1BPPARG | |
| SCHEMBL5375295 | 0.81 | CYP3A4 (0.47) | CYP3A4FNTAFNTBPGGT1BP2RX3 | |
| SCHEMBL5364632 | 0.81 | CYP3A4 (0.47) | CYP3A4FNTAFNTBPGGT1BP2RX3 | |
| SCHEMBL4801931 | 0.80 | CYP3A4 (0.55) | CYP3A4FNTAFNTBPGGT1BP2RX3 | |
| SCHEMBL4807122 | 0.77 | CYP3A4 (0.47) | CYP3A4CYP2C9CYP2C19KCNH2MTNR1B | |
| SCHEMBL4805444 | 0.75 | CYP3A4 (0.45) | CYP3A4FNTAFNTBPGGT1BCYP2C9 | |
| SCHEMBL4807235 | 0.73 | APOBEC3G (0.40) | CYP3A4FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL5364936 | 0.73 | PRMT5 (0.40) | CYP3A4FNTAFNTBPGGT1BP2RX3 | |
| SCHEMBL14570769 | 0.73 | CYP3A4 (0.53) | CYP3A4FNTAFNTBPGGT1BP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348345-B2 | Nonnucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | DUNN JAMES P | 2007-08-02 | — | — | US | disclosed |
| US-7208509-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | RRM2, RRM2B, SAMHD1 | CYP3A4 438/4885FNTA 1982/4885FNTB 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.