Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480222 | 0.86 | ALOX5AP (0.67) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL480237 | 0.86 | ALOX5AP (0.64) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL480199 | 0.84 | ALOX5AP (0.62) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL10198935 | 0.84 | ALOX5AP (0.62) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL480198 | 0.84 | ALOX5AP (0.62) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL10197150 | 0.82 | ALOX5AP (0.70) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL13262105 | 0.78 | ALOX5AP (0.66) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL480227 | 0.78 | ALOX5AP (0.63) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL3000715 | 0.77 | ALOX5AP (0.57) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL480286 | 0.77 | ALOX5AP (1.00) | ALOX5APMKNK1MKNK2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALOX5AP 14/4885MKNK1 4255/4885MKNK2 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.