Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.46 |
| ▸ | HTR7 | P34969 | 8/20 | 0.46 |
| ▸ | HTR6 | P50406 | 15/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784223 | 0.90 | HTR1A (0.42) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4784467 | 0.89 | HTR6 (0.42) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4784470 | 0.89 | HTR6 (0.42) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4784203 | 0.88 | HTR6 (0.43) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4782045 | 0.88 | HTR6 (0.45) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL14207899 | 0.88 | HTR6 (0.43) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4783875 | 0.88 | HTR6 (0.56) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4781961 | 0.87 | HTR6 (0.42) | HTR1AHTR7HTR6DRD2HTR2A | |
| SCHEMBL4782531 | 0.86 | SFRP1 (0.53) | HTR1AHTR7 | |
| SCHEMBL14208234 | 0.85 | HTR6 (0.49) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |