Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | GCKR | Q14397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480242 | 1.00 | ALOX5AP (0.74) | ALOX5APLMNAMAPTGCKGCKR | |
| SCHEMBL2998157 | 0.88 | ALOX5AP (0.64) | ALOX5APLMNAMAPT | |
| SCHEMBL480259 | 0.86 | ALOX5AP (1.00) | ALOX5APLMNAMAPTGCKGCKR | |
| SCHEMBL480221 | 0.86 | ALOX5AP (1.00) | ALOX5APLMNAMAPTGCKGCKR | |
| SCHEMBL480230 | 0.81 | ALOX5AP (0.60) | ALOX5APLMNAMAPT | |
| SCHEMBL480207 | 0.80 | ALOX5AP (0.65) | ALOX5APGCKGCKR | |
| SCHEMBL480232 | 0.80 | ALOX5AP (0.65) | ALOX5APGCKGCKR | |
| SCHEMBL3000897 | 0.80 | ALOX5AP (0.87) | ALOX5APLMNAMAPTGCKGCKR | |
| SCHEMBL480235 | 0.80 | ALOX5AP (0.62) | ALOX5AP | |
| SCHEMBL707655 | 0.78 | ALOX5AP (0.80) | ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | claimed |
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | claimed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALOX5AP 14/4885LMNA 1616/4885MAPT 4793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.