Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | RGS12 | O14924 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.62 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094368 | 0.85 | ALDH1A1 (1.00) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL28960465 | 0.82 | ALDH1A1 (0.60) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL4625771 | 0.82 | CES1 (0.59) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL12176977 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL13401392 | 0.79 | ALDH1A1 (0.86) | ALDH1A1MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL11377406 | 0.78 | HPGD (0.61) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL28960488 | 0.78 | KMT2A (0.67) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL11373726 | 0.77 | HPGD (0.63) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL2795967 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16047533 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9143159-A | — | — | None | — | — | JP | disclosed |
| JP-9087248-A | — | — | None | — | — | JP | disclosed |
| US-10653676-B2 | Small molecule inhibitors of USP1 deubiquitinating enzyme activity | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20170202810-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-07-20 | — | — | US | disclosed |
| US-9518032-B2 | Small molecule inhibitors of USP1 deubiquitinating enzyme activity | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-13 | — | — | US | disclosed |
| US-20130253005-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2013174-B1 | DIARYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME (US) | 2013-05-08 | — | — | EP | disclosed |
| EP-2013174-B1 | DIARYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME (US) | 2013-05-08 | — | — | EP | disclosed |
| EP-0668256-B1 | Process for preparing a water-soluble organic oxide | COSMO SOGO KENKYUSHO KK (JP) | 1997-10-15 | — | — | EP | disclosed |
| JP-H09143159-A | PRODUCTION OF 5-PHTHALIMIDO-4-OXOPENTENOIC ACID PYRIDINE SALT | COSMO SOGO KENKYUSHO:KK | 1997-06-03 | — | — | JP | disclosed |
| JP-H0987248-A | PRODUCTION OF 5-PHTHALIMIDO-4-OXOPENTENOIC ACID OR ITS PYRIDINE SLAT | COSMO SOGO KENKYUSHO:KK | 1997-03-31 | — | — | JP | disclosed |
| EP-0607952-B1 | Process for preparing 5-aminolevulinic acid | COSMO SOGO KENKYUSHO KK (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5554766-A | OXIATION | COSMO RESEARCH INSTITUTE (JP) | 1996-09-10 | — | — | US | disclosed |
| EP-0668256-A1 | Process for preparing water-soluble organic oxides such as 5-aminolevulinic acid | COSMO RESEARCH INSTITUTE (JP) | 1995-08-23 | — | — | EP | disclosed |
| US-5380935-A | Process for preparing 5-aminolevulinic acid | COSMO RESEARCH INSTITUTE (JP) | 1995-01-10 | — | — | US | disclosed |
| EP-0607952-A1 | Process for preparing 5-aminolevulinic acid | COSMO RESEARCH INSTITUTE (JP) | 1994-07-27 | — | — | EP | disclosed |
| EP-0523846-A2 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0272866-A1 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1988-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130253005-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | USP1, USP2, USP28 | ALDH1A1 1183/4885KDM4E 934/4885MEN1 2034/4885 |
| US-10653676-B2 | Small molecule inhibitors of USP1 deubiquitinating enzyme activity | USP1, USP2, USP28 | ALDH1A1 1183/4885KDM4E 934/4885MEN1 2034/4885 |
| US-20170202810-A1 | SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY | USP1, USP2, USP28 | ALDH1A1 1183/4885KDM4E 934/4885MEN1 2034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.