Sugi Predict

Sugi Predict / Compounds / SCHEMBL4803489

SCHEMBL4803489

SCHEMBL4803489

COc1ccn2c(C=O)cnc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FLT3 P36888 4/20 0.41
▸ PRMT5 O14744 1/20 0.41
▸ WDR77 Q9BQA1 1/20 0.41
▸ ALDH1A1 P00352 5/20 0.39
▸ KIT P10721 4/20 0.38
▸ MAPT P10636 1/20 0.37
▸ ERN1 O75460 1/20 0.36
▸ TRIM24 O15164 1/20 0.36
▸ TYR P14679 1/20 0.36
▸ TRIM33 Q9UPN9 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ PKM P14618 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ PDE10A Q9Y233 1/20 0.35
▸ RIPK2 O43353 1/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ PDE3B Q13370 1/20 0.35
▸ PDE3A Q14432 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5634440 0.79 ALDH1A1 (0.51) FLT3PRMT5WDR77ALDH1A1MAPT
SCHEMBL21863416 0.77 FLT3 (0.48) FLT3PRMT5WDR77ALDH1A1KIT
SCHEMBL24997460 0.77 ALDH1A1 (0.41) ALDH1A1ERN1KDM4EHPGDNPC1
SCHEMBL23888973 0.76 SIK2 (0.35) FLT3ALDH1A1KITRIPK2
SCHEMBL20049151 0.76 ALDH1A1 (0.41) ALDH1A1ERN1KDM4EPKM
SCHEMBL25246761 0.76 PRMT5 (0.38) FLT3PRMT5WDR77ALDH1A1KDM4E
SCHEMBL23132777 0.76 FLT3 (0.43) FLT3PRMT5WDR77ALDH1A1KIT
SCHEMBL16581904 0.76 FLT3 (0.43) FLT3PRMT5WDR77ALDH1A1KIT
SCHEMBL16898417 0.76 FLT3 (0.43) FLT3PRMT5WDR77ALDH1A1KIT
SCHEMBL9941702 0.74 KDM4E (0.43) FLT3PRMT5WDR77ALDH1A1KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION 2025-12-23 — — US disclosed
US-20250059184-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. 2025-02-20 — — US disclosed
US-20240217991-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2024-07-04 — — US disclosed
WO-2023114844-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF DELIX THERAPEUTICS, INC. (US) 2023-06-22 — — WO disclosed
US-20220396588-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2022-12-15 — — US disclosed
CN-107922396-B Colony stimulating factor-1 receptor (CSF-1R) inhibitors 建新公司 2022-08-05 — — CN disclosed
US-11274108-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION (US) 2022-03-15 — — US disclosed
US-20190016707-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION 2019-01-17 — — US disclosed
EP-3325471-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS Genzyme Corporation (US) 2018-05-30 — — EP disclosed
WO-2017015267-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2017-01-26 — — WO disclosed
CN-101133056-B Antitumor compounds NAT HEALTH RESEARCH INSTITUTES 2010-12-01 — — CN disclosed
US-7456289-B2 Anti-tumor compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2008-11-25 — — US disclosed
US-7456289-B2 Anti-tumor compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2008-11-25 — — US disclosed
US-7456289-B2 Anti-tumor compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2008-11-25 — — US disclosed
CN-101133056-A Antitumor compounds NAT HEALTH RESEARCH INSTITUTES (CN) 2008-02-27 — — CN disclosed
EP-1838711-A2 ANTI-TUMOR COMPOUNDS National Health Research Institutes (TW) 2007-10-03 — — EP disclosed
WO-2006074041-A2 ANTI-TUMOR COMPOUNDS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2006-07-13 — — WO disclosed
US-20060148801-A1 Anti-tumor compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2006-07-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11274108-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN FLT3 8/4885PRMT5 668/4885WDR77 2283/4885
US-20240217991-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN FLT3 8/4885PRMT5 668/4885WDR77 2283/4885
US-20060148801-A1 Anti-tumor compounds TUBB1, TUBB3, TUBB FLT3 1769/4885PRMT5 2625/4885WDR77 2099/4885
US-20250059184-A1 IMIDAZOPYRIDINE PSYCHOPLASTOGENS AND USES THEREOF GRIN2A, GAP43, GRIN2C FLT3 3395/4885PRMT5 1087/4885WDR77 1748/4885
US-20220396588-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN FLT3 8/4885PRMT5 668/4885WDR77 2283/4885
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN FLT3 7/4885PRMT5 1096/4885WDR77 3149/4885
US-20190016707-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN FLT3 8/4885PRMT5 668/4885WDR77 2283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.