Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14994480 | 0.80 | PGR (0.36) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5518051 | 0.79 | PGR (0.88) | PGR | |
| SCHEMBL16245004 | 0.78 | PGR (0.34) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL26640132 | 0.75 | PGR (0.39) | PGRKMT2A | |
| SCHEMBL30642103 | 0.75 | PGR (0.39) | PGRKMT2A | |
| SCHEMBL26640534 | 0.75 | PGR (0.37) | PGR | |
| SCHEMBL31559921 | 0.73 | ALDH1A1 (0.33) | PGRALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL15579040 | 0.73 | PGR (0.44) | PGRBACE1MEN1KMT2A | |
| SCHEMBL19629948 | 0.73 | PGR (0.41) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4805389 | 0.72 | SLC6A2 (0.47) | PGRALDH1A1BACE1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114050-A1 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | WYETH (US) | 2008-05-15 | — | — | US | disclosed |
| US-7317037-B2 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | WYETH (US) | 2008-01-08 | — | — | US | disclosed |
| CN-1993123-A | Progesterone receptor modulators containing pyrrole-oxindole derivatives and uses thereof | WYETH CORP (US) | 2007-07-04 | — | — | CN | disclosed |
| CN-1980660-A | Contraceptive regimens and kits for progesterone receptor antagonists | WYETH CORP (US) | 2007-06-13 | — | — | CN | disclosed |
| EP-1773323-A1 | PROGESTERONE RECEPTOR ANTAGONIST CONTRACEPTIVE REGIMENS AND KITS | Wyeth (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006017075-A1 | PROGESTERONE RECEPTOR ANTAGONIST CONTRACEPTIVE REGIMENS AND KITS | WYETH (US) | 2006-02-16 | — | — | WO | disclosed |
| US-20060030717-A1 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | WYETH (US) | 2006-02-09 | — | — | US | disclosed |
| US-20060009509-A1 | Progesterone receptor antagonists, contraceptive regimens, and kits | WYETH (US) | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030717-A1 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | PGR, PGRMC2, PGRMC1 | PGR 1/4885ALDH1A1 2361/4885HPGD 147/4885 |
| US-20080114050-A1 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | PGR, PGRMC2, PGRMC1 | PGR 1/4885ALDH1A1 2361/4885HPGD 147/4885 |
| US-20060009509-A1 | Progesterone receptor antagonists, contraceptive regimens, and kits | GNRHR, PGRMC2, PGR | PGR 3/4885ALDH1A1 2936/4885HPGD 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.