Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802754 | 0.78 | DHFR (0.42) | BCL6SYKALDH1A1L3MBTL1ADORA1 | |
| SCHEMBL4801168 | 0.78 | SYK (0.54) | BCL6SYKKDM4EALDH1A1RAB9A | |
| SCHEMBL4802208 | 0.75 | SYK (0.44) | BCL6SYKKDM4ERAB9AAURKA | |
| SCHEMBL4802062 | 0.74 | SYK (0.57) | BCL6SYKAURKAADORA1 | |
| SCHEMBL27612421 | 0.72 | SYK (0.42) | BCL6SYKSMN1; SMN2ADORA1 | |
| SCHEMBL4799243 | 0.71 | RPS6KA3 (0.41) | BCL6SYKKDM4EALDH1A1FGFR1 | |
| SCHEMBL4803374 | 0.71 | RPS6KA3 (0.41) | BCL6SYKSRCADORA1 | |
| SCHEMBL4801395 | 0.70 | SYK (0.76) | BCL6SYKRAB9AADORA1 | |
| SCHEMBL27612690 | 0.70 | RPS6KA3 (0.38) | BCL6SYK | |
| SCHEMBL4805640 | 0.69 | ADORA2A (0.46) | BCL6SYKALDH1A1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329672-B2 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-12 | — | — | US | disclosed |