Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285531 | 0.83 | OPRM1 (0.48) | OPRM1OPRD1P2RX3CACNA1GCACNA1B | |
| SCHEMBL580286 | 0.82 | OPRM1 (0.48) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3696595 | 0.81 | OPRM1 (1.00) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4806009 | 0.80 | OPRM1 (0.51) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL11946734 | 0.79 | OPRM1 (0.57) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL10476541 | 0.78 | OPRM1 (0.63) | OPRM1OPRD1P2RX3OPRK1GRIN2D | |
| SCHEMBL11945496 | 0.78 | OPRM1 (0.60) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL14159393 | 0.78 | OPRM1 (0.60) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL4809645 | 0.77 | OPRM1 (0.70) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL1532866 | 0.77 | OPRM1 (0.70) | OPRM1OPRD1OPRK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699783-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-07-25 | — | — | EP | disclosed |
| EP-1699783-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-07-25 | — | — | EP | disclosed |
| US-7414132-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414132-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414132-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-20070112036-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112036-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112036-A1 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-05-17 | — | — | US | disclosed |
| EP-1699783-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005066164-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112036-A1 | Opioid receptor antagonists | OPRM1, OPRD1, OPRK1 | OPRM1 1/4885OPRD1 2/4885P2RX3 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.