Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | PLD2 | O14939 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885693 | 0.85 | OPRL1 (0.65) | OPRL1ADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL11647483 | 0.85 | CHRM1 (0.69) | OPRL1CHRM1DRD2KCNH2OPRM1 | |
| SCHEMBL5984390 | 0.84 | OPRL1 (0.75) | OPRL1CHRM1DRD2KCNH2OPRM1 | |
| SCHEMBL11395925 | 0.84 | OPRL1 (0.71) | OPRL1OPRM1HTR1A | |
| SCHEMBL4812163 | 0.84 | OPRL1 (0.66) | OPRL1OPRM1PLD1ADRB2ADRB1 | |
| SCHEMBL4802544 | 0.84 | OPRL1 (0.66) | OPRL1CHRM1DRD2KCNH2OPRM1 | |
| Hydrochloric Acid SCHEMBL4798788 | 0.83 | OPRL1 (0.65) | OPRL1CHRM1DRD2KCNH2OPRM1 | |
| SCHEMBL11644820 | 0.83 | OPRM1 (0.67) | OPRL1CHRM1DRD2KCNH2OPRM1 | |
| SCHEMBL11648914 | 0.83 | OPRL1 (0.75) | OPRL1CHRM1DRD2KCNH2OPRM1 | |
| SCHEMBL11380381 | 0.82 | OPRL1 (0.64) | OPRL1CHRM1DRD2KCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | disclosed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | disclosed |